Anmol Chemicals is the pioneer manufacturers of Isatoic Anhydride, Pharmaceutical Excipients Fragrance & Flavor chemicals in India. We offer Halal and Kosher Isatoic Anhydride made in an ISO9001:2008, ISO22000:2005 (FSSC22000) and cGMP certified facility. Our group has several manufacturing facilities spread across the world, supported by toll manufacturers and representatives in UAE, Europe, Africa, USA, China and has several associated manufacturing facilities spread across India. All the Information on Physics, Chemistry, Applications, Uses and Technology on Manufacture of Isatoic Anhydride is in these pages.
The units have one or more of the certifications like FDA GMP, ISO 9001, ISO 22000, HACCP, REACH, Kosher & Halal

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Isatoic Anhydride SDS GHS, MSDS Sheet

Specifications of Isatoic Anhydride

Isatoic Anhydride Hexahydrate SDS GHS, MSDS Sheet, Material Safety Data Sheet

1. Product Identification

Synonyms: 4H-3,1-benzoxazine-2,4(1H)-dione; 1,2-Dihydro-4H-3,1-benzoxazine-2,4-dione; 2H-3,1-Benzoxazine-2,4(1H)-dione; Anthranilic Acid, N-carboxy-, Cyclic Anhydride; Isatoic Acid Anhydride; Benzoic Acid, 2-(Carboxyamino)-, Cyclic Anhydride; N-carboxyanthranilic Anhydride; 4H-3,1-benzoxazina-2,4(1H)-diona (Spanish); Anthranilic acid N-carboxylic acid anhydride.
CAS No.
: 118-48-9
EINECS: EC Number: 204-255-0
Molecular Weight: 163.13
Chemical Formula: C8H5NO3
Recommended usage: Industrial Manufacturing.

2. Hazards Identification

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Sensitization, Skin Category 1
Serious eye damage/eye irritation Category 2A

Labeling according to GHS & Regulation (EC) No 1272/2008

GHS Label Elements
Irritant
Irritant

Signal Words: Warning

Hazard statements:
H317: May cause an allergic skin reaction.
H319: Causes serious eye irritation.

Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash skin thoroughly after handling.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+352: IF ON SKIN: Wash with soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.
P333+313: If skin irritation or a rash occurs: Get medical advice/attention.
P337+P313: If eye irritation persists: Get medical advice/ attention.
P360: Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container in accordance with local/regional/national/international regulations.


Classification according to EU Directives 67/548/EEC or 1999/45/EC:
R43
Xi Irritant R36
For the full text of the H-Statements & R-phrases mentioned in this Section, see Section 16.

OSHA Hazards: Skin sensitizer, Irritant.

3. Composition/Information on Ingredients

Ingredient: Isatoic Anhydride
CAS No.: 118-48-9
EINECS: EC Number: 204-255-0
Percent: 97 - 100%

4. First Aid Measures

Always seek medical attention after first aid measures are provided.

Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Wipe off excess material from skin then immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.
Note to Physician: Treat symptomatically.

5. Fire Fighting Measures

Flammability of the Product: The product is flammable.
Auto-Ignition Temperature: 350.
Flash Points: 308C.
Products of Combustion: It forms oxides of carbon nitrogen and toxic gases when heated to decomposition. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Explosion: Not known.
Fire Extinguishing Media
: Use water spray, dry chemical, foam, or carbon dioxide.
Special Information
 In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures or when moistened under fire conditions, it may produce toxic or irritating fumes.

6. Accidental Release Measures

Small Spill: Avoid dust formation. Avoid breathing dust. Ensure adequate ventilation. Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.
Large Spill: Do not let the product enter drains. Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water and swab.

7. Handling and Storage

Do not breathe dust. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment.
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Wash hands thoroughly after handling. Provide appropriate exhaust ventilation at places where dust is formed. If you feel unwell, seek medical attention.
Keep Isatoic Anhydride in a tightly closed container, stored in a cool, dry, ventilated area. Protect against physical damage or contact with oxidizing material and combustible substances. Avoid moisture and store away from water sources.

8. Exposure Controls/Personal Protection

Airborne Exposure Limits: None established.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

9. Physical and Chemical Properties

Appearance: Isatoic Anhydride is tan colored crystals or powder.
Odor: Typical
Solubility: Readily soluble in water.
pH: 5.6
Molecular Weight: 163.13
Molecular Formula: C8H5NO3
% Volatiles by volume @ 21C (70F): 0
Boiling Point: NA
Melting Point: 235-237 C Decomposes

10. Stability and Reactivity

Stability: Isatoic Anhydride is stable under recommended conditions of use and storage.
Hazardous Decomposition Products: It produces oxides of carbon nitrogen along with toxic fumes when heated to decomposition.
Hazardous Polymerization: Will not occur.
Incompatibilities: Isatoic Anhydride is incompatible with water including moisture, heat, oxidizing material, strong acids & alkalis.
Conditions to Avoid: Moisture, Heat, Sun light, Incompatibles.

11. Toxicological Information

RTECS: CAS# 118-48-9: DM3100000
Toxicity to Animals:
Oral, mouse: LD50 = NA
Oral, rat: LD50 = NA
Carcinogenic Effects: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
Mutagenic Effects: Not available.
Teratogenic Effects: Not available.
Developmental Toxicity: Not available.

12. Ecological Information

Environmental Toxicity:
Toxicity to fish: No data found
Toxicity to daphnia and other aquatic invertebrates: No data found
Biodegradability: -
BOD and COD: Not available.

13. Disposal Considerations

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused Isatoic Anhydride in accordance with federal, state and local requirements.

14. Transport Information

DOT (USA)
Not Regulated.
IMDG
Not Regulated.
IATA
Not Regulated.

15. Regulatory Information

USA:
OSHA Hazards
: Skin Sensitizer, Irritant.
SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
Section 313: No chemicals are reportable under Section 313.
SARA 311/312 Hazards
: Acute Health Hazard.
TSCA: CAS# 118-48-9 is on the TSCA Inventory.
CERCLA Hazardous Substances and corresponding RQs: -.
Health & Safety Reporting List: None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules: None of the chemicals in this product are under a Chemical Test Rule.
Section 12b: None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule: None of the chemicals in this material have a SNUR under TSCA.
California Prop 65: Not listed.
Massachusetts Right To Know Components: Not listed.
Pennsylvania Right To Know Components: 4H-3,1-Benzoxazine-2,4(1H)-dione, CAS-No.: 118-48-9
New Jersey Right To Know Components: 4H-3,1-Benzoxazine-2,4(1H)-dione, CAS-No.: 118-48-9
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product are listed as Hazardous Substances under the CWA.
None of the chemicals in this product are listed as Priority Pollutants under the CWA.
None of the chemicals in this product are listed as Toxic Pollutants under the CWA. 
WGK (Water Danger/Protection): CAS# 118-48-9: 1 

Canada - WHMIS: CAS# 118-48-9 is not listed on Canada's Ingredient Disclosure List.

HMIS (Perceived): Health hazard: 2, Flammability: 1, Physical hazards: 0
NFPA (Perceived): Health hazard: 2, Fire: 1, Reactivity Hazard: 0

Section 16 - Additional Information

EINECS: EC Number: 204-255-0
H317 = May cause an allergic skin reaction.
H319 = Causes serious eye irritation.
Xi = Irritant
R36 = Irritating to eyes.
R43 = May cause sensitization by skin contact.
Safety Phrases: S 24/25 Avoid contact with skin and eyes. S 37 Wear suitable gloves. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). S 28A After contact with skin, wash immediately with plenty of water.

Disclaimer:
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Our company provides this Isatoic Anhydride SDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This Isatoic Anhydride MSDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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Isatoic Anhydride Isotoic Anhydride Manufacturers

Anmol Chemicals
S-8, SARIFA MANSION, 2ND FLANK ROAD, CHINCHBUNDER, MUMBAI 400009, INDIA
TEL: (OFFICE) 91-22-23770100, 23726950, 23774610, 23723564 - FAX: 91-22-23728264

e-mail: anmolc@mtnl.net.in

Anmol Chemicals

Isotoic anhydride manufacturers uses

Exports to USA, Canada, UAE, Dubai, South Africa, Tanzania, Kenya, Nigeria, Egypt, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Europe Netherlands, Italy, Spain, Germany, Portugal, France, Malaysia, Indonesia, Thailand, Korea, Japan,etc.

Copyright and Usual Disclaimer is Applicable. 23 March, 2016